Rosie O’Donnell knows when to hold em…and knows when to fold em.

The comedian and co-host of “The View” dropped a double bomb on Friday evening by announcing she and her wife, Michelle Rounds, have split after three years of marriage.

Not only that…Rosie also announces she’s also leaving “The View” to focus on her children and next week will be her last week.

Peep the scoop from Page Six below.

Rosie’s rep, Cindi Berger, confirmed the marital split, as well O’Donnell’s departure from “The View,” in a statement Friday night: “I can confirm that Rosie and her wife Michelle split in November. Rosie has teens and an infant at home that need her attention. This has been a very stressful situation. She is putting her personal health and family first. ABC has been wonderfully understanding and supportive of her personal decision to leave ‘The View.’ Next week will be her last.”

O’Donnell, 52, married her second wife Rounds in private in June 2012. In 2013, they adopted a baby girl, Dakota. She has four other older kids..

ABC also released a statement confirming Rosie’s departure and wished her well as she concentrates on her family.

Rosie is an immensely talented star who comes in each and every morning brimming with ideas, excitement and passion for the show. When she told us she wanted to exit ‘The View,’ we respected and understood her desire to put her well-being and her family first. We’re delighted she’s still part of the ABC family with upcoming guest appearances on ‘The Fosters,’ and we know she’ll return to ‘The View’ often with her unique point of view and updates on her work and her family.

It’s sad to hear Rosie O’Donnell has had another marriage fall apart, but the news of her leaving “The View” is no surprise. It was pretty much inevitable based on the way she and Whoopi Goldberg have been bumping heads…on and off camera.